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Catabolic sulfur reduction

Organic sulfur metabolites are catabolized up to sulfate, which in turn is excreted via the urine. The final step of the pathway -the reduction of sulfite to sulfate - is dependent on the molybdenum-containing enzyme, sulfite oxidase. Both, a genetic disorder of sulfite oxidase synthesis or a molybdenum deficiency will reduce the urinary excretion of sulfate, but increase that of sulfite, S-sulfocysteine and thiosulfate. Due to the toxic effect of sulfite on the nervous system, this disease is characterized by mental retardation and dislocation of ocular lenses (Rajagopalan 1988). A marginal amount of molybdenum or sulfite oxidase worsen the sulfite detoxification of the... [Pg.1313]

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See also in sourсe #XX -- [ Pg.457 ]



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