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Castro-Stephens reaction copper acetylide preparation

Castro and Stephens developed a method for the preparation of unsymmetrical disubstituted acetylenes, which involves the reaction of copper(I) acetylides with aromatic iodo compounds. Bond and Hooper extended this route to the preparation of 2-aryIisatogens (22). 2-Nitro-phenylpropiolic acid (19a) is readily decarboxylated to the acetylene (19b), which on treatment with copper (I) chloride gives 19c. The reaction of 19c with substituted aromatic iodo compounds (20) gives the corresponding acetylenes (21), which subsequently cyclize to the isatogens (22). The alternative route (23 + 24 - 21) has been little used. ... [Pg.128]

See other pages where Castro-Stephens reaction copper acetylide preparation is mentioned: [Pg.61]    [Pg.46]    [Pg.424]    [Pg.393]    [Pg.215]    [Pg.517]    [Pg.13]    [Pg.234]    [Pg.39]    [Pg.217]    [Pg.14]   
See also in sourсe #XX -- [ Pg.231 ]



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Acetylide

Acetylides

Castro

Castro reaction

Copper acetylides

Copper preparation

Stephen

Stephen reaction

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