Castle, William

D.R. Williams, Highly functionalized ethylene-vinyl acetate emulsion copolymers, US Patent 6762239, assigned to National Starch and Chemical Investment Holding Corporation (New Castle, DE), July 13, 2004. 

For instance, on the early consideration of these protein drugs see William Castle to A. N. Richards, 14 May 1958, Richards Papers, box 16, folder 24 Anon., 8 June 1961, Report of Merck Institute Scientific Advisors Meeting, Ibid., box 21, folder 11 Anon., 23 December 1963, Report of Merck Institute Scientific Advisors, Meeting of October 27, 28 and 29, Ibid., box 16, folder 50. On erythropoietin, interferon, human insulin, and the nature of recent biologist-industrialist interactions see, e.g., A. Kornberg, The Golden Helix Inside Biotech Ventures (Sausalito, 1995). 

Bi2 (2). Corrinoids are sequestered from food sources by a glycoprotein of mass 45kDa called intrinsic factor, which is secreted in the stomach and binds B12 derivatives very tightly (for CN-Cbl, iC = 1.5 X 10 mol dm ). Several other proteins bind and transport B12 into cells (3). The disease pernicious anemia has been recognized since the early nineteenth century and linked to a deficiency of what William Castle called extrinsic factor (i.e., vitamin B12) in 1928 (1). This disease develops because of the failure of the patient to secrete sufficient intrinsic factor. 

Pryor JP, Castle WM, Dukes DC, Smith JC, Watson ME, Williams JL. Do beta-adrenoceptor blocking drugs cause retroperitoneal fibrosis BMJ (Clin Res Ed) 1983 287(6393) 639 1. 

Hans Deuel, Paul Guthrie, William Moody, Leland Deck, Stephen Lange, Farhan Hameed, Jeremy Castle, and Linda Meams, Potential impacts of climate change on air quality and human health, presented at 92nd Annual Meeting of Air and Waste Management Association, St. Louis, 1999. 

Walter Reed Army Medical Center BBTS Bethany Beach Tng Site, DE William Nelson Armor New Castle De... 

President asked for advice about how the federal government could assist In scientific and medical research In the period following the Second World War. The members of the Medical Advisory Committee were, except for myself, physicians Walter W. Palmer, Homer W. Smith, Kenneth B. Turner, William B. Castle, Edward A. Dolsey, Ernest Goodpasture, Alton Ochsner, and James J. Waring. 

After a strenuous day listening to representatives of medical schools and medical research institutes in New York City, the members of the Medical Advisory Committee were having dinner together at a club in the city (19). Dr. William B. Castle, Professor of Medicine at Harvard University, began talking about the disease sickle-cell anemia, with which he had had some experience. I had only a mild interest in what he was saying, because at that time cells seemed to me to be far too complex to permit me to make any sort of attack on them. However, when Dr. 

The king had been liberated on parole from his confinement in Carisbrooke Castle and was allowed to occupy a house in Newport. (The treating was to take place in the Town Hall.) The petitioners were correct in thinking that he (and his son) would plead that any agreement he made was made under duress and was therefore not binding on him. He was soon (about 8 October) to plan an escape with the aid of his host, William Hopkins. 

Farey, J. 1816. A letter from Dr. William Richardson to the Countess of Gosford (occasioned by the Perusal of Cuvier s Geological Essay ) describing the Arrangement of the Strata for 60 Miles on the South and as many on the North of Gosford Castle, in the Armagh County in Ireland. Communicated by Mr. John Farey, Sen. with some preliminary Remarks and illustrative Notes by him, Phil. Mag. 47, 354-364. 

The story of the intrinsic factor involves as well the whole story of pernicious anemia and of vitamin B12. William Bosworth Castle, the discoverer of the intrinsic factor, has described the history of The Conquest of Pernicious Anemia, but only those parts will be touched on here that are needed to make the story of the intrinsic factor intelligible. 

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