Caspase behavior

Transfection of Caspase 14 cDNA Altered Tumor Cell Behavior.127... 

The stress or growth pathways modulated by vanadium involve specialized effectors and often can be activated by excess ROS. Cytokines, small proteins that effect communication between cells or cell behavior, can be involved in the cellular stress response. Tumor necrosis factor a (TNFa) is a cytokine stress signal that binds to a membrane receptor (tumor necrosis factor receptor, or TNFR). This interaction stimulates kinase activity that leads to cell injury and inflammation and also to the activation of caspases, a family of cysteine-dependent aspartate-directed proteases that are involved in apoptosis. The mitogen-activated protein (MAP) kinase cascade regulates both mitosis and apoptosis signaling pathways. 

Fish and fish oil components, EPA, and DHA are of benefit in Alzheimer s disease (209-211). A reduction in dietary DHA in an Alzheimer s mouse model showed a loss of postsynaptic proteins associated with increased oxidation and showed increased caspase-cleaved actin, which was localized in dendrites however, DHA-restricted mice when given DHA were protected against dendritic pathology and behavioral deficits and showed increased antiapoptotic BAD phosphorylation, which implies that DHA could be useful in preventing Alzheimer s disease... 

Satoh K, Kaneko K, Hirota M et al. The pattern of CPP32/caspase-3 expression reflects the biological behavior of the human pancreatic duct cell tumors. Pancreas 2000 21 352-357. 

---