Cases Collected from the

Shehadi and Toniolo (453)in 1980 reported the result of a survey on the safety of intravascular ionic contrast media in more than 300,000 cases collected from the United States, Canada, Europe, and Australia and showed that the overall incidence of reactions was slightly below 5%, with neither significant geographic or racial differences nor differences related to age, sex, and weight. Most of the patients were in their third and fourth decade of life. 

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