Case studies hERG channel

Finally, it is important to remember that, in case of racemic drugs, it is important to resort to stereoselective methods to detect possible differences in the actions of the test compounds at the desired target and hERG channels. For instance, a recent study detected differences between (R)- and (S)-methadone [115]. 

Hancox, J.C. and Mitcheson, J.S. (2006) Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine a case-study in cardiac safety pharmacology. British Journal of Pharmacology, 149, 457 159. 

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