Carrier proteinaceous

After binding to a proteinaceous membrane carrier, drugs are carried across the membrane (with the expenditure of cellular energy), where they are released... 

One of the limitations of the use of a proteinaceous carrier is the relative small number of drug molecules that can be conjugated without gross alterations in the structure of the protein. For example, extensive derivatization of an antibody carrier may lead to the loss of its... 

A new, simple method for the covalent attachment of proteins to polysaccharides has been described. An agarose carrier was derivatized by treatment with 4-benzoquinone in ethanol, and the proteinaceous material was then coupled directly stable immobilized derivatives of serum albumin, ribonuclease, and chymotrypsin were obtained by this technique. Another advantage of the method is that coupling occurs over a wide range of pH. 

The nature of the carrier represents an open question, and only its isolation and identification can provide an appropriate answer. Considering substrate specificity, which is characteristic for carrier-mediated transport, it is very likely that the substrate binding site is proteinaceous, because protein possesses selective behavior. This presumption... 

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