Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Carlo modeling of the chromatin fiber

An important addition compared to previous models was the parameterization of the internucleosomal interaction potential in the form of an anisotropic attractive potential of the Lennard-Jones form, the so-called Gay-Berne potential [90]. Here, the depth and location of the potential minimum can be set independently for radial and axial interactions, effectively allowing the use of an ellipsoid as a good first-order approximation of the shape of the nucleosome. The potential had to be calibrated from independent experimental data, which exists, e.g., from the studies of mononucleosome liquid crystals by the Livolant group [44,46] (see above). The position of the potential minima in axial and radial direction were obtained from the periodicity of the liquid crystal in these directions, and the depth of the potential minimum was estimated from a simulation of liquid crystals using the same potential. [Pg.410]

In order to connect the chromatin chain and to model the effect of the linker histone, DNA and chromatosomes were linked either at the surface of the [Pg.410]

One result of the simulations was that the torsion angle q between successive nucleosomes determines the properties of the structure to a great extent (as also predicted by the two-angle model). While a variation in the internucleosome interaction potential by a factor of four changes that simulated mass density by only about 5%, this quantity is very sensitive to variations in twist angle (see Fig. 6 in Ref. [50]). [Pg.411]


See other pages where Carlo modeling of the chromatin fiber is mentioned: [Pg.410]   


SEARCH



Carlo Modeling

Chromatin

Chromatin fiber

Chromatin fiber models

Modeling of Chromatin

© 2024 chempedia.info