Carijoa chlorinated pregnanes

The polychlorinated androstanes clionastatins A (659) and B (660) were isolated from the burrowing sponge Cliona nigricans (Fig. 3.10) collected in two locations along the Italian coast (761). These unique metabolites have good cytotoxic activity against murine and human cancer cell lines. The eastern Pacific octocoral Carijoa multiflora has yielded the unusual chlorinated pregnanes 661 and 662 in a chloroform-free isolation process (762). 

Dorta E, Dtaz-Marrero AR, Cueto M, D Croz L, Mate JL, San-Martin A, Darias J (2004) Unusual Chlorinated Pregnanes from the Eastern Pacific Octocoral Carijoa multiflora. Tetrahedron Lett 45 915... 

Dorta, E Diaz-Marrero, A.R., Cueto, M., D Croz, L., Mate, J.L., San-Martin, A., and Darias, (. (2004b) Unusual chlorinated pregnanes from the Eastern Pacific octocoral Carijoa multijlora. Tetrahedron Lett., 45,915-918. 

---