Cargo groups

Chemical Compatibility Classification — The U.S. Coast Guard defines 43 cargo groups listed in Navigation and Vessel Inspection Circular No. 4-75, "Guide to Compatibility of Chemicals."... 

Soon after the discovery of the ability of SPG to complex homopolynucleotides, it was demonstrated that schizophyllan complexes with poly(A) or poly(C) will dissociate at pH 4—6 [45]. This property is important as SPG polyplexes could potentially release their polynucleotide cargo in the acidic pH environment of endosomes and/or lysosomes. However, since these polyplexes possess a net negative charge and lack targeting groups, they are inefficient in terms of cellular internalization. 

The vectors currently under investigation that employ nonclassical transport represent a diverse group of entities. This diversity has required that a variety of protocols be developed for both the conjugation of the vectors to cargo molecules and the presentation of the vector-cargo complex to the target cells. In this section, an overview of the methods most commonly employed for vector production is presented. For more detailed information on the actual protocols, the reader is referred to the specific references mentioned herein. 

In general, the placement of reactive functionalities on the exterior surface of the dendrimers allows introduction of a wide variety of terminal moieties. In alternate synthetic approaches, spacer groups have been deliberately introduced to relieve the steric hindrance in order to faciUtate construction of the next generation. This may provide the possibility of enhancing interior cargo spaces for guest-host type chemistry. ... 

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