Neuroleptics cardiotoxicity

Overall, amoxapine appears to have some advantage over other tricyclic antidepressants possible earlier onset of action and relative freedom from serious cardiotoxic effects. Its major drawbacks are the potential for neuroleptic adverse effects, a high incidence of seizures, deaths in overdose (2), and the possibility of long-term neurological damage. 

Overdosage toxidty Poisoning with antipsychotics other than thioridazine is not usually fatal. Hypotension often responds to fluid replacement. Neuroleptics lower the convulsive threshold and may cause seizures, which are usually managed with diazepam or phenytoin. Thioridazine overdose, because of cardiotoxicity, is more difficult to treat. 

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