Cardiac hypertrophy induction

Friddle CJ et al. Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci USA 2000 97 6745-6750. 

The Role of PKC and Calcium in Gq-Dependent Induction of Concentric Cardiac Hypertrophy... 

McMullen, J., Shioi, T., Zhang, L., Tamavaski, O., Sherwood, M.C., Kang, P.M., and Izumo, S. 2003. Phosphoinositide 3-kinase (pi 10a) plays a critical role for the induction of physiological, but not pathological cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 100 12355-12360. 

Arnott et al. (1998) have used phenylephrine treated neonatal rat cardiac myocytes as a model of cardiac hypertrophy for proteomic analysis. In this 2-D-based study, 11 protein spots displayed statistically significant changes in expression upon induction of hypertrophy. Of these, eight showed higher expression and three were decreased in abundance in hypertrophied cells. All of... 

Shubieta, H.E., McDonough, PM., Harris, A.N., Knowlton, K.U., Glembotski, C.C., Brown, J.H., and Chien, K.R. 1990. Endothelin induction of inositol phosphate hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J.Biol. Chem. 265 20555-20562. 

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