Cardiac failure definition

MedDRA also provides Standardized MedDRA Queries (SMQs) to help summarize the data. SMQs may pull PTs from one or more SOCs. One example is cardiac failure, whose codes may occur both in the cardiac SOC as "cardiac failure" or some variant thereof and the respiratory SOC as "pulmonary edema." Bleeding is another important SMQ because people may experience bleeds in a variety of organ classes. Many SMQs have narrow or broad definitions with the latter necessarily including more PTs. 

Acute myocardial infarction can be limited by streptokinase which dissolves fresh clots and opens the artery, but muscle death and necrosis causes a mechanical defect. Subsequent infarcts cause further muscle death and ultimately lead to defective ventricular function and cardiac failure. There is the need for simple alarm systems to detect acute myocardial infarction and less traumatic invasive procedures to dissolve the clot and dilate the artery immediately. Coronary arteries ramify and branch in 3-dimensional space and the present generation of balloon catheters for percutaneous transluminal coronary angioplasty carries a small but definite risk. New, non-traumatic guidewires, low profile dilatation systems and more powerful dilatation balloons which will not rupture the artery are needed. 

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