Carcinogenicity of ethylene dibromide

Powers MB, Voelker R, Page N, et al Carcinogenicity of ethylene dibromide (EDB) and l,2-dibromo-3-chloropropane and oral administration in rats and mice (abstr). Toxicol Appl Pharmacol 33 171-172, 1975... 

The lARC has determined that there is inadequate evidence in humans but sufficient evidence in experimental animals for the carcinogenicity of ethylene dibromide. An overall evaluation of probably carcinogenic to humans is given. A threshold limit exposure limit has not been assigned by ACGIH. 

There is inadequate evidence in humans for the carcinogenicity of ethylene dibromide. 

Dietary pretreatment with DDT decreased the incidence of mammary tumors induced by dimethyl benzanthracene (21). Carcinogenicity of ethylene dibromide has been shown (18) to be increased by exposure to disulfiram. Induction of lung benzo(a)pyrene hydroxylase by carbaryl paralleled an Increase in lung tumors induced by benzo(a)pyrene (19). In the same experiments, pretreatment with toxaphene decreased the incidence of lung adenomas (19) and this correlated with the inhibition of lung benzo(a)pyrene hydroxylase. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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