Carcinogenesis complete” carcinogens

In contrast to BP, benzo(e)pyrene (BeP) is generally considered to be inactive as a complete carcinogen (38). The only vicinal diin Polycyclic Hydrocarbons and Carcinogenesis Harvey, R. ... 

Toxicology. Indenol(l,2,3-ci)pyrene (IP) is a complete carcinogen and an initiator for skin carcinogenesis in the mouse. ... 

Kurokawa Y, Takamura N, Matsushima Y, et al. 1984. Studies on the promoting and complete carcinogenic activities of some oxidizing chemicals in skin carcinogenesis. Cancer Lett 24 299-304. 

Some agents are complete carcinogens, that is, they act as both initiators and promoters of carcinogenesis. These include... 

Complete Carcinogenesis Studies. Studies in laboratory animals have demonstrated the ability of benz[a]anthracene, benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[a]pyrene, chrysene, dibenz[a,h,]anthracene, and indeno[1,2,3-c,d]pyrene to induce skin tumors (i.e., they are complete carcinogens) following intermediate dermal exposure. Anthracene, fluoranthene, fluorene, phenanthrene, and pyrene do not act as complete carcinogens. The data supporting these conclusions are discussed below by chemical. Only those studies considered adequate and reliable with respect to study design and adequacy of reporting are presented in Table 2-3. 

Wynder and Hoffmann in their lengthy 1964 review of tobacco carcinogenesis (4319) discussed tobacco smoke as a complete carcinogen and in their evaluation of the role of tobacco smoke components in experimental carcinogenesis listed radicals with the comment that radicals are suggested as possible carcinogens in disagreement with the experiments [see p. 391, Table XXII in (4319)]. 

In this study, we confirm that adipocytes can incorporate /i-PAH and /-PAH in a similar manner and that B[a]P in addition to its mutagenic carcinogenic properties can significantly inhibit lipolysis. So because adipocytes can incorporate both mutagenic and promoting PAHs, we conclude that PAHs cocktails may be equivalent to complete carcinogens and that the adipose tissue may play a key role in PAH-induced carcinogenesis. 

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