Carboxymethyl dextran-CPT analogue T-2513 conjugate

An attractive approach was developed by Vicent et al. containing the bioactive agent as an integral part of the polymer backbone. Polyacetals were synthesised incorporating a drug with bishydroxyl functionality into the polymer backbone. Degradation of the polymer backbone in the acidic environment of the lysosome or the extracellular fluid of some tumours woifld 

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