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Carboxylic acids oxygen-alkylated

A large number of studies in the literature describe prodrugs of carboxylic acids incorporating alkyl groups functionalized with oxygenated, nitro-... [Pg.442]

The functional group of a carboxylic ester (commonly referred to simply as an ester) is an acyl group bonded to —OR or —OAr. Both lUPAC and common names of esters are derived from the names of the parent carboxylic acids. The alkyl or aryl group bonded to oxygen is named first, followed by the name of the acid, in which the suffix -ic acid is replaced by the suffix -ate ... [Pg.491]

The dianions derived from furan- and thiophene-carboxylic acids by deprotonation with LDA have been reacted with various electrophiles (Scheme 64). The oxygen dianions reacted efficiently with aldehydes and ketones but not so efficiently with alkyl halides or epoxides. The sulfur dianions reacted with allyl bromide, a reaction which failed in the case of the dianions derived from furancarboxylic acids, and are therefore judged to be the softer nucleophiles (81JCS(Pl)1125,80TL505l). [Pg.72]

In the oxaziridines (1) ring positions 1, 2 and 3 are attributed to oxygen, nitrogen and carbon respectively. The latter almost always is in the oxidation state of a carbonyl compound and only in rare cases that of a carboxylic acid. Oxaziridinones are not known. The nitrogen can be substituted by aryl, alkyl, H or acyl the substituent causes large differences in chemical behavior. Fused derivatives (4), accessible from cyclic starting materials (Section 5.08.4.1), do not differ from monocyclic oxaziridines. [Pg.196]

Esters are named by first identifying the alkyl group attached to oxygen and then the carboxylic acid, with the -ic acid ending replaced by -ate. [Pg.787]

The carbocations generated by non-Kolbe electrolysis can rearrange by alkyl, phenyl or oxygen migration. The migratory aptitudes of different alkyl groups have been studied in the rearrangement of a-hydroxy carboxylic acids (Eq. 34) [323]. [Pg.133]

Still another method for the conversion of halides to acid derivatives makes use of Na2Fe(CO>4. As described in 10-112, primary and secondary alkyl halides and tosylates react with this reagent to give the ion RFefCO) (142) or, if CO is present, the ion RCOFe(CO)4 (143). Treatment of 142 or 143 with oxygen or sodium hypochlorite gives, after hydrolysis, a carboxylic acid. " Alternatively, 142 or 143... [Pg.565]

Additional BHT-derived 5-LO inhibitors bear heteroatom-linked 4-substituents. Searle s SC-45662 (50) was selective (25 1) for 5-LO over CO in cRBL (3.7 /iM) and in A23187-stimulated RBL-1 cells (7.1 yuM) [146]. Besides NSAID-like activity in RAA (down to 10 mg/kg p.o.), SC-45662 also inhibited GPB (ED30 16.7 mg/kg p.o.), and LTB4 release from ulcerative colitis rectal mucosal biopsy samples was decreased [147]. Several patents have described similar compounds where the alkyl substituent on sulphur is varied quite widely [148 151]. Oxidation of the distal sulphur was consistent with activity, while replacement of this sulphur with oxygen gave reduced potency. Simple alkyl groups, alkylene-linked esters and amides, and disulphide-linked alkanoic esters were also active in cRBL with similar potency free carboxylic acids were somewhat less potent. Oxidation of the sulphur attached to the phenolic ring destroyed the activity. [Pg.13]

The basic structure of humic substances involves a backbone composed of alkyl or aromatic units crosslinked mainly by oxygen and nitrogen groups. Major functional groups attached to the backbone are carboxylic acids, phenolic hydroxyls, alcoholic hydroxyls, ketones, and quinones. The molecular structure is variable as it is dependent on the collection of DOM available in seawater to undergo the various polymerization, condensation, and oxidation reactions and reaction conditions involved in humification, as well as the ambient physicochemical reaction conditions, such as temperature and light availability. [Pg.637]

SYNTHESIS and CHARACTERIZATION of O-ALKYLATED EXTRACTS. Alkylation occurs when tetrabutylanunonium hydroxide is used to promote the reaction of the alkyl iodide with the coal in tetrahydrofuran.(14) The alkylation reaction occurs primarily on acidic oxygen functionalities such as phenolic hydroxyl and carboxylic acid groups, as shown below. [Pg.142]


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See also in sourсe #XX -- [ Pg.28 ]




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Alkyl carboxylate

Alkyl carboxylates

Alkyl carboxylic acid

Alkylation oxygen

Carboxyl oxygen

Carboxylate alkylation

Carboxylates alkylation

Carboxylic acids alkylated

Carboxylic acids alkylation

Oxygen acids

Oxygen carboxylate

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