Carboxylic acids fermentation inhibition

CJ-13,981 (45) and CJ-13,982 (46) were isolated from the fermentation broth of CL 15036, an unidentified fungus, as new squalene synthase inhibitors. They inhibited human liver microsomal squalene synthase with IC50 values of 2.8 and 1.1 pM, respectively. Based on the spectroscopic analyses, the structures of CJ-13,981 and CJ-13,982 were elucidated to be highly carboxylated fatty acids, 3-hydroxy-3,4-dicarboxy-15-hexadecenoic acid (45) and 3-hydroxy-3,4-dicarboxyhexa-decanoic acid (46), respectively [70]. 

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