Carboxyli acid

Thiadiazole-4-carboxylie acids biological activity, 6, 462 photochemistry, 6, 462... 

CN [2S-(2a,5a,6P)]-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1 -azabicydo [3.2.0]heptane-2-carboxylie acid... 

CN 10J/-phenothiazine-10-carboxylie acid 2-[2-(dimethylamino)ethoxy]ethyl ester... 

CN hexahydro-1-methy 1-4-phenyl-lH-azepine-4-carboxylie acid ethyl ester citrate (1 1)... 

Control (H,0) Anthracene-9- carboxylie acid Ethacrynic acid Brefeldin-A... 

Cyclization of diethyl [3-(4-acetyl-l-piperazinyl)-4-fluorophenyl-l,3-thiazetidin-2-ylidene]malonate (1291) in polyphosphoric acid at 120°C for 1 hr gave a mixture of l,3-thiazeto[3,2-a]quinoline-3-carboxylate (1292, R = Et 25%) and 3-carboxylie acid (1292, R = H 20%) (87BRP2190376). Ring closure was also carried out in fuming sulfuric acid at 100°C for 5 min to afford l,3-thiazeto[3,2-fl]quinoline-3-carboxylic acid (1292, R = H) in 98% yield. 

N-nitrosothiazolidine-4-carboxylie acid N-nitrosothiazolidine polynuclear aromatic hydrocarbons polynuclear aromatic compounds peroxy acetyl nitrate... 

Grignard reagents react with carbon dioxide (dry iee) to form salts of carboxylie acids which in turn give eorresponding earboxylic acids after aeidifleation with mineral acid. 

In this report, poly(carboxylie acid) containing hydroxyl. 

We can appreciate that ionization of the carboxylie acid is affected by the electron-withdrawing inductive effect of the ammonium residue hence the increased acidity when compared with an alkanoic acid. Similarly, loss of a proton from the ammonium cation of the zwitterion is influenced by the electron-donating inductive effect from the carboxylate anion, which should make the amino group more basic than a typical amine. That this is not the case is thought to be a solvation effect (compare simple amines). 

In another approaeh [88IJC(B)570], reaetion of 2-mereapto-4,5-di-p-tol-ylimidazole 43 with a-halo carboxylie acids enabled the synthesis of several imidazo[2,l-h]thiazoles. Acylative ring closure of 4,5-di-p-tolylimidazo-2-thioacetic acid (44, R = H) or 2-thiopropionic acid (44, R = Me) provides 5,6-di-p-tolylimidazo[2,l-h]thiazole-3(2//)-one (45, R = H) or its 2-methyl analog (45, R = Me). The synthesis of annelated imidazo[2,l-h]thiazoles (e.g., 46) can be achieved in one step by reaction of 2,3-dichloroquinoxaline with 43. The intramolecular eyelization of l-vinylimidazole-2-thiones to 2,5-dimethyl-3,6-arylimidazo[2,l-h]thiazoles with excellent yield has been reported (93T6619). 

Trifluoroniethyl)luran-.3-carboxylie Acid (8) Typical Procedure 150... 

H-Pyrrole-3-carboxylie acid, ethyl ester, 3C NMR, 4, 172 <74JCS(P2)1004)... 

Benzo[b]tellurophene-2-carboxylie acids reactions, 4, 952 Benzotellurophenes, 4, 935-971 mass spectra, 4, 22 synthesis, 4, 103 Benzo[ b]tellurophenes acetylation, 4, 946, 948... 

H-Dibenzo[6,e]thiin-9-carboxylie acids as fungicides, 3, 941 10H-Dibenzo[l ,e]thiinium salts reactions... 

The extraction of some metal ions by di(2-ethylhexyl)phosphoric acid is shown in Figure 9.7 The order of extraction of the divalent metals of the first transition series, viz. Zn > Cr > M > Cu > Fe > Co > Ni > V, shows important differences from that observed with carboxyli acid extractants, particularly with respect to the relative positions of zinc and copper and of coba... 

To a 250 ml three-neck round bottom flask was added 10.0 g (32.01 mmol) of (8p)-l-isopropyl-6-methylergoline-8-carboxylie acid, 4.43 g (32.1 mmol) of potassium carbonate and 200 ml of N,N-dimethylformamide. The mixture was refluxed and 25 ml of a distillate was collected. The remaining solution was cooled in an ice bath, and then with an acetonitrile/carbon dioxide bath which lowered the temperature of the reaction mixture to about -45°C this mixture was added 4.59 g (33.62 mmol) of isobutyl chloroformate dropwise. The resulting mixture was stirred for approximately 5 min and 3.49 g (35.21 mmol) of cyclohexylamine was added. The reaction mixture was allowed to warm to room temperature and stirred for approximately 19 h. To the mixture was added 500 ml of ice water containing 25 ml of concentrated ammonium hydroxide. The mixture was cooled and the precipitated solid was collected by vacuum filtration. The resulting solid was washed with water and dried in vacuo to provide 10.13 g (yield 76.8%) of the (8P)-N-cyclohexyl-l-isopropyl-6-methylergoline-8-carboxamide having a purity of 92.3%. 

Ami no-1 -ethy 1-7-methy lamino-4-oxo-1, 4-dihydro-1,8-naphthyridine-3-carboxylie acid >300 1029... 

CN 8-ethyl-5,8-dihydro-5-oxo-2-( 1 -piperazinyl pyndo[2,3-t/]pyrirnidine-6-carboxylie acid trihydrate... 

C6H7NO,S2 174139 70-9) see Brinzolamidc (3a,16a)-14,15-dihydro-19-thioxo-l,14-secoeburname-ninc-14-carboxylie acid methyl ester (C2 H2,N70,S 23944-40-3) see Vincamine... 

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