Carboxylesterases regulation

Satoh T, Hosokawa M (2006) Structure, function and regulation of carboxylesterases. Chem Biol Interact 162 195-211... 

Although proteinuria is often considered to be a pathological event, we demonstrated that this is not the case for the domestic cat. Male cat urine contains a large amount of the mammalian carboxylesterase family member termed cauxin. Cauxin is excreted in a species-, sex-, and age-dependent manner and regulates the production of felinine, a putative pheromone precursor. This finding provides an example of a previously unknown type of proteinuria involved in chemical communication. 

M. Hosokawa, T. Maki, T. Satoh, Multiplicity and Regulation of Hepatic Microsomal Carboxylesterases in Rats , Mol. Pharmacol. 1987, 31, 579-584 M. Hosokawa, T. Satoh, Effects of Hypophysectomy and Pituitary Hormones on Hepatic Microsomal Carboxylesterase Isozymes in Male Rats , Res. Commun. Chem. Pathol. Pharmacol. 

Hosokawa, M., Satoh, T. (2006). Structure, function, and regulation of carboxylesterases. In Toxicology of Organophosphate and Carbamate Compounds (R.C. Gupta, ed.), pp. 219-31. Academic Press/Elsevier, Amsterdam. 

Yan, B., Yang, D., Bullock, P., Parkinson, A. (1995). Rat serum carboxylesterase, cloning, expression, regulation, and evidence of secretion from liver. J. Biol. Chem. 270 19128-34. 

Staudinger JL, Xu C, Cui YJ, Klaassen CD (2010) Nuclear receptor-mediated regulation of carboxylesterase expression and activity. Expert Opin Drug Metab Toxicol 6(3) 261-271.doi 10.1517/17425250903483215... 

Hosokawa, M., Maki, T, and. Saioh, T. (1987). Multiplicity and regulation of hepatic miciosomal carboxylesterases in rats. Mol. Pharmacol. 31,579-584. 

Zhu, W., Song, L, Zhang, H., Maloney, L., LeCluyse, E, and Yan, B. (2000). Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab. Dispos. 28, 186-191. 

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