Carboxylates oxidation

Carboxylation/Oxidation of Straight-Chain 1-Olefins. Selective carboxylation of a-olefins to predominately straight-chain aldehydes is realized through specific catalyst systems and by careful control of reaction conditions. The aldehyde produced is then air-oxidized to the acid using a Mn catalyst. Heptanoic acid [111-14-8] and pelargonic acid [112-05-0] are produced commercially in this manner. 

The rigid, planar pyridine analog 111 was isolated in low yield by first hydrolyzing the known (67) pyridine diethyl phosphonate 109 to the corresponding free acid 110 followed by permanganate oxidation (2). An alternative synthesis of 111 has recently been reported (68). Alkylation of pyridine-2-carboxylate -oxide with dimethylsulfate and subsequent reaction with the sodium salt of diethyl phosphite gave the triester 112, which was readily converted to 111. 

Pre-Inoculation Steps Determination and optimization of an adaptive co-metabolic and symbiotic bio-products system to achieve both, hemicycle A (carboxylation/oxidative stage) and hemicycle B (decarboxylation/reductive stage), and of the sequence and timing of events in terms of bio-products inoculation to accomplish the RACDC. 

The different substituents have different electron donating/accepting properties and hence affect electron density and the acidity of the carboxyl group through which adsorption takes place. Electron accepting groups on the aromatic ring weaken the carboxylate-oxide surface bond. 

One can find many more examples where a subtle modification in a side chain leads to a new drug that produces a drastically different therapeutic or toxicological outcome. This is clearly illustrated by the nonsedating antihistamine terfenadine (Seldane), which produces cardiotoxicity when given with certain drugs that inhibits its metabolism. This product is no longer marketed. It has been replaced by its safer but no less effective carboxylic oxidative metabolite fexofenadine (Allegra). 

Y. Fujiwara, Acc. Chem. Res. 2001, 34, 633-639 (d) Y. Fujiwara, C. Jia, Palladium-Catalyzed Carboxylative Oxidation of Arenes, Alkanes, and Other Hydrocarbons, in Handbook of Organopalladium Chemistry for Organic Synthesis,... 

Polycyclic phenolic humic substances produce phenol carboxylates (oxidation of adjacent rings) of the salicylate type and possibly 3-ketoenolates (El(L) = -0.08 V for both acac" and sal2 )... 

Organometalhc compounds based on lead, tin, bismuth and zinc are also used to catalyse a urethane reaction. Bismuth and zinc carboxylates are used because of the toxicity and disposal problems of lead and tin. Nowadays, alkyl tin carboxylates, oxides and mercaptide oxides such as dibutyltin dUaurate (DBTDL),dioctyltin mercaptide, stannous octoate and dibutyltin oxide are used successfully in all types of polyurethane applications (Table 6.4), among which DBTDL was found to be the most widely used catalyst. The catalytic effect of organometaUic compounds is due to their capacity to form a complex with the isocyanates and polyols. The catalysis mechanism involves interaction of the metal cation with isocyanate and hydroxyl groups, followed by rearrangement of the resulting complex to yield the final urethane product. 

Carbon (usually of unspecified type) is among the electrode materials that have been used but its advantages and comparison of performance with other materials and, indeed, between forms of carbon are seldom discussed. It is only as scale-up and process costs become important, that carbon becomes important and more thoroughly investigated. The product selectivity can certainly depend on the electrode material. An oft-quoted example is the oxidation of carboxylates at Pt and C anodes where the trend is for Pt to give products from radical intermediates and C to give products from carbenium ion intermediates. It should, however, be noted that the products from carboxylate oxidation also depend on solvent, pH, current density, temperature, and so on, so that simple conclusions can be misleading. 

The diorganotin carboxylic oxides and hydroxides are summarized in the new chapter for easier reference. Many compounds probably form a four-membered stannoxane ring as set forth in the main volume, page 336. 

Additional diorganotin carboxylate oxides and hydroxides are listed in Table... 

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