Carboxyhomoyessotoxin from mussels

Carboxyhomoyessotoxin (221) was isolated from the digestive glands of mussels from the northern Adriatic Sea [226]. Two further analogues of yessotoxin, carboxyyessotoxin (222) and 42,43,44,45,46,47,55-heptanor-41-oxohomoyessotoxin (223) were isolated. Carboxyyessotoxin (222) was isolated from DSP-infested M. galloprovincialis from the Italian Coast of the Adriatic Sea [227], while 42,43,44,45,46,47,55-heptanor-41-oxohomoyessotoxin (223) was also isolated from digestive glands of mussels from the northern Adriatic. The structure of compound 223 was determined by NMR spectroscopy and mass spectrometry [228]. 

Two new analogs of YTX, carboxyyessotoxin (carboxyYTX, 8) and carboxyhomoyessotoxin (carboxyhomoYTX, 9) (Figure 13.1), were reported in 2000 from the digestive glands of mussels collected in July 1997 and autumn 1998, respectively, from the Emilia Romagna coast of Italy. Their structures were determined by MS and mono- and bi-dimensional NMR experiments. 

Ciminiello, R, Fattorusso, E., Forino, M., Roletti, R., and Viviani, R., Structure determination of carboxyhomoyessotoxin, a new yessotoxin analog isolated from Adriatic mussels, Chem. Res. Toxicol., 3, 770. 2000... 

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