Carboxyhemoglobin formation

Burn injvuy —> inhalation of smoke and ashes alveoli blockage carbon monoxide inhalation -4 carboxyhemoglobin formation (carbon monoxide binding to oxygen receptors) heat damage to bronchioles and alveoli -> damage and collapse of alveoli hypoxia and hypercarbia (elevated carbon dioxide) with related imbalances... 

Carboxyhemoglobin carbon monoxide Blood 4-6 h No Traffic, body formation... 

Carbon monoxide is eliminated via the lungs. Dissociation and excretion of carbon monoxide occur rapidly after cessation of exposure but slow as carboxyhemoglobin levels decrease. Cardiovascular injury can result from carboxymyoglobin formation and vasodilation from cellular effects of carbon monoxide. Clinical neurological effects and any delayed neurological sequelae can be attributed to asphyxia as well as lipid peroxidation, and hypotension, which induce ischemic-reperfusion injury. 

ACUTE HEALTH RISKS irritation of eyes, skin and throat dizziness headache drowsiness confusion central nervous system depression pulmonary edema may cause effects on blood, resulting in the formation of carboxyhemoglobin lowering of consciousness. 

Tumor-associated or therapy-induced anemia can lead to a reduced O2 transport capacity of the blood, a major (systemic) factor contributing to the development of hypoxia (anemic hypoxia). This type of hypoxia is especially pronounced in tumors or tumor areas exhibiting low perfusion rates. A. similar condition can be caused by carboxyhemoglobin (HbCO) formation in heavy smokers, which leads to a functional anemia, since hemoglobin blocked by carbon monoxide (CO) is no longer capable of transporting oxygen. 

The equilibrium constant for the formation of carboxyhemoglobin is about 250 times larger than that for oxyhemoglobin. The result is that breathing carbon monoxide deprives the cells of oxygen, and the victim is ultimately asphyxiated. A few hemoglobin... 

In this case, hemoglobin is the receptor (Section 23.7) acted on by the carbon monoxide toxicant. Carboxyhemoglobin is much more stable than oxyhemoglobin, so that its formation prevents hemoglobin from binding with ojg gen and carrying it to body tissues. 

Fig. 8. The formation of a w-bond between carbon monoxide and Fe(II) in carboxyhemoglobin. The orbital of Fe(II) is used in the formation of a...

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