Carborane functionalized dendronized

Synthesis and Characterization of Carborane Functionalized Dendronized Polymers as Potential Boron Neutron Capture Therapy Agents... 

SCHEME 27.10 Synthesis of functional carborane-containing dendrons based on a polyester backbone 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) scaffold. 

The versatility of the carborane cluster allows it to act as a scaffold to extend the dendron from the carbon atoms to the periphery or to be modified as a focal point. Yamamoto and coworkers reported on the synthesis of polyols of a cascade type as water-solubilizing groups of carborane derivatives for BNCT. Small carbosilane dendrons in which a cZoio-carborane is located at the focal point have been prepared by a sequence of steps involving hydrosilylation and reduction reactions. These compounds are used as scaffolds for peripheral functionalization with styrene, chlorovinylstyrene, or suitable carboranes, while keeping the C..,us, -Si (C..-Si) bond (Scheme 27.2). Besides, the reaction involving nucleophilic attack by fluoride or other nucleophiles, and the subsequent cleavage of C -Si bonds, is a well-documented process in carboranylsilane chemistry. Thus, the possibility to... 

Several reactions could be carried out in ILs solvents examples are transition-metal-catalyzed hydrogenation, hydroformylation, isomerization, dimerization, and coupling reactions (Holbrey and Seddon, 1999b). Carborane derivatives could also be synthesized successfully in ILs such as l-n-butyl-3-methylimidazolium chloride (Li et al., 2008) the same IL was used for the preparation of functional carboranyl-containing dendrons (Galie et al., 2006 Mollard and Zharov, 2006). 

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