Carboplatin emetogenicity

Like carboplatin, oxaliplatin does not usually cause nephrotoxicity. In addition, both drugs are only moderately emetogenic, in contrast to cisplatin. The most important dose-limiting adverse effect of oxaliplatin is a sensory peripheral neuropathy, which has two different forms ... 

Nausea, vomiting, and diarrhea are common adverse effects of oxaliplatin and carboplatin, but they are generally mild to moderate, and both are less emetogenic than cisplatin. However, patients who have previously received cisplatin may be at greater risk of vomiting with carboplatin or oxaliplatin (1,8,9). 

Myelosuppression thrombocytopenia, neutropenia, anemia moderately emetogenic risk of hypersensitivity reactions, frequently delayed, after 5-E doses may necessitate discontinuation of carboplatin frequently results in cross-hypersensitivity to cisplatin... 

Another organometallic platinum drug has been approved in the United States. It is a diammin platinum coordinate with 1,1-cyclobutanedicarboxylic acid named carboplatin (CBDA, Paraplatin). Its advantages over cisplatin are a lesser emetogenic effect as well as a possible decrease in nephro- and ototoxicity. 

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