Carbonyl additions and organometallic chemistry in water

The Barbier reaction is that between an alkyl halide and a carbonyl compound in the presence of magnesium (Barbier, 1898). In Barbier-type reactions, an organometallic intermediate species is supposed to be produced in the presence of the substrate. As this organometallic intermediate is usually highly reactive with water, Barbier-type reactions were previously conducted after careful exclusion of water. 

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A. Lubineau, J. Auge, Y. Queneau, Carbonyl Additions and Organometallic Chemistry in Water in Organic Synthesis in Water (Ed. P. A. Grieco), Blacky Academic and Professional, London, 1998, pp.102-140. 

Lubineau, A., Auge, J., Queneau, Y. Carbonyl additions and organometallic chemistry in water. Organic Synthesis in Water). 1998,102-... 

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