Carbon-oxygen double bonds asymmetric transfer

In this chapter and in Chapters 10-12, we will review and validate some methods for asymmetric (transfer) hydrogenation of carbon-oxygen and carbon-carbon double bonds catalysed by non-metallic systems, homogeneous transition metal catalysts and biocatalysts. Reduction of carbon-nitrogen double bond systems will be reported in another volume of this series. 

An obvious extension of the AD-process would be the asymmetric transfer of heteroatoms other than oxygen to a carbon carbon double bond. Indeed, the osmium catalyzed [3] or palladium mediated [4] aminohydroxylation of alkenes has been known for 20 years. The resulting jff-amino alcohols are an important structural element in biologically active compounds as well as the starting point in the design of many chiral ligands. However, to develop this reaction into a catalytic, asymmetric process several problems had to be overcome. 

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