Carbon Nanotube cellular uptake

Jin, H. et al. (2009) Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes single particletracking and a generic uptake model for nanoparticles. ACS Nano, 3 (1), 149-158. 

Kostarelos, K. et al. (2007) Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nature Nanotechnology, 2 (2), 108-113. 

Raffa V, Ciofani G, Vittorio O, Riggio C, Cuschieri A. Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomedicine 2010 5 89-97. 

It has been proved that MWCNTs and single-walled carbon nanotubes (SWCNTs) differ in their cell penetration mechanism. Confocal microscopy imaging has shown that SWCNTs have the ability to be internalized into cells, whereas MWCNTs are not capable to enter to the cells. The size of the CNTs also influences their cellular uptake and fate, because long SWCNTs (L-SWCNTs) have been shown to be localized in the cytoplasm, while short SWCNTs (S-SWCNTs) are transported into the nucleus [30]. 

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