Carbon monoxide physiologic effects

Parts of carbon monoxide per million parts of air Carbon monoxide Physiological effects in %/vol. ... 

Wilks, S.S., Tomashefski, J.F., Clark, R.T. (1959). Physiological effects of chronic exposure to carbon monoxide. J. Appl. Physiol. 14 305-10. 

Penney, D. G., Helfman, C. C., Dunbar, J. C., McCoy, L. E. (1991). Acute severe carbon monoxide exposure in the rat Effects of hyperglycemia and hypoglycemia on mortality, recovery, and neurological deficit. Canadian Journal of Physiology, 69, 1168-1177. 

In some cases toxic effects are due to the interaction between the compound and a specific molecular receptor site. This receptor might be an enzyme which could be inhibited, or some other macromolecule, or a receptor with a normal physiological function, but in many cases its identity is unknown. Two examples of toxicity where the receptor is known are carbon monoxide which interacts specifically with haemoglobin and cyanide which interacts specifically with the enzyme cytochrome a3 of the electron... 

Nitroglycerin is a heavy, colorless, oily liquid, which has a sweet taste and, as ordinarily prepared, a pale yellow color. It freezes at about 8°, melts at about 12°, and explodes when, heated to 180°. Small quantities burn in the open air without explosion. Nitroglycerin is very sensitive to shocks, and can readily be exploded by a sharp blow. It is a powerful poison, resembling strychnine somewhat in its physiological effects. It is used as a remedy in heart disease, and is injected into the blood in cases of poisoning by carbon monoxide or water-gas. 

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