Carbon monoxide interaction with myoglobin

Spencer and Schaumburg 2000). Although the primary reaction of carbon monoxide is with hemoglobin, it also interacts with myoglobin, cytochromes, and metalloenzymes (e.g., cytochrome c oxidase and cytochrome P450) (WHO 1999). The health importance of these secondary reactions is not well understood. 

Of course, the current direction is to synthesize complexes which will more closely mimic hemoglobin and myoglobin and to develop oxygenactivating species in general. In 1973 and 1974, several model systems were devised. We will thus be concerned here with the interaction of molecular oxygen (dioxygen) and carbon monoxide with metalloporphyrin complexes as models of biologically important hemoproteins. 

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