Carbon disulfide , in urine

Some investigators have measured levels of carbon disulfide in urine as a biomarker of exposure, but this is probably optimal only for measuring high exposure levels (Beauchamp et al. 1983). Good correlation between urinary carbon disulfide levels and work exposure was not found in any studies. The measurements of excreted or "free" carbon disulfide may have been confounded by the presence of various thiometabolites or "bound" species. Moreover, the volatility of carbon disulfide and individual variations in urinary flow rate and metabolism may have confounded results in these studies (Djuric 1967). 

The assessment of internal exposure is made by testing biomarkers -metabolites of carbon disulfide in urine. The samples were collected in the end of the working shift. The results were re-calculated based on creatinine. The correction of the results vs. creatinine excretion is applied for reducing the confounding factors, respectively to eliminate the external and internal factors that are not associated with exposure to carbon disulfide. 

Total metabolites of carbon disulfide in urine - molJ2/mmol creatinine (iodine-azide test)... 

The results obtained categorically confirm the adequate choice of biomarkers for assessment of internal exposure. The determination of specific metabolites of carbon disulfide in urine can be widely applied, as the methods are specific and non-invasive. As mentioned above the only source of TTCA appearance is the inhaled carbon disulfide. It should be underlined that the high correlation between external and internal exposure proves the credibility of the used sampling strategy and implemented GC methods for determination of carbon disulfide concentrations in workplace... 

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See also in sourсe #XX -- [ ]

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