Carbon Bond Formation with Acylsilanes

Carbon-Carbon Bond Formation with Acylsilanes 

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Carbon-Carbon Bond Formation with Acylsilanes... 

The reaction of acylsilanes with appropriate carbon nucleophiles, followed by the Brook rearrangement, provides a novel source of carbanions which can be further elaborated on treatment with a reactive electrophile, allowing the formation of two carbon-carbon bonds in a one-pot reaction. 

The diastereo-selective synthesis of protected CM-2-aminocyclopropanols has been performed by the reaction of A-f-butylsulfinyl ketimines with acylsilanes. A cascade transformation involving the formation of two carbon-carbon bonds and an oxygen-silicon bond is a key feature of this reaction. 

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