Carbometallation Reactions of Allenes

From stereoselective (/-PrO)4Ti, c-CjHgMgCI carhometallation EtsO, -78 to -50 °C (2) KF, KHCO3, H2O2, 

This allene-aikene reductive cross-coupling is an attractive method for the stereoselective synthesis of Z,E)- and (Z,Z)-trisubstituted 1,3-diene scaffolds from readily available isomericaUy pure allenyl alcohols [126]. 

Carbometallation reactions remain one of the most powerful tools for carbon-carbon bond formations. The past decade of scientific explorations in this area of organometaUic chemistry has witnessed an even increased level of sophistication that incontrovertibly confirms the significance of the considered strategy in organic 

Tertiary Alcohols 40 by Alkylation/Arylation Reactions of Alkenylcarbamates and Quenching with t-BuONO 

Morton, M. (1983) Anionic Pofymeriza-tion Principles and Practice, Academic Press, New York. 

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