Carbohydrate conjugates, 1,2,3-triazol

Carbohydrate Conjugates Containing Multiple 1,2,3-Triazole Heterocydes. 150... 

Glicosphingolipids are very important membrane components of eukaryotic cells and play a fundamental role in various stages of the cell cycle. Recently, the synthesis of triazol-hased neoglycolipids was published by Rivera and coworkers. It was based on Ugi-4CR/CuAAC combination and this type of approach was not yet explored for synthesis of triazol-linked carbohydrate-lipid conjugates. NMR analysis of the triazol-based glycolipids at room temperature showed the occurrence of two conformers and dynamic NMR experiment allowed to evaluate the free energy of activation of the isomerization of the cisitrans amide bond. 

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