Carbodiimides toxicity

N-Hydroxythiopyridone 2(1H)-Pyridinethione, 1-hydroxy- (8,9) (1121-30-8) Dicyclohexylcarbodiimide highly toxic. Carbodiimide, dicyclohexyl- (8) Cyclohexanamine, N,N -methanetetraylbis- (9) (538-75-0)... 

The alkyl-, alky laryl- and diarylcarbodiimides are the diimides derived from carbon dioxide, however, no direct formation of carbodiimides from amines and carbon dioxide is known. Interestingly, carbodiimides can be obtained from amines and carbon dioxide via a switteri-onic titanium complex (see Section 2.2.8). The major starting materials for the synthesis of carbodiimides are isocyanates, 1,3-disubstituted ureas or 1,3-disubstituted thioureas. The synthesis of isocyanates requires the use of the toxic carbonyl chloride or its oligomers. A book on the synthesis and reactions of isocyanates appeared in 1996. ... 

Carbodiimides generally are the most potent acaricides however, they are often toxic to fish and some show only limited crop tolerance. 

Hazardous Decomp. Prods. On decomp., emits toxic fumes of NOx Storage Light-sensitive Uses Activator to decrease racemization in carbodiimide peptide couplings Manuf./Distrib. Aldrich http //www.sigma-aldrich.com, Fluka http //www.sigma-aidrich.com, Schweizerhall http //www.susinc.com] Sigma... 

Diisopropyl carbodiimide is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker. 

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