Carbapenems orally active

In terms of activity there seems little to prevent some of these compounds finding a place in therapy, especially those such as SCH 29482, SUN 5555, and FCE 25199 which have oral absorption properties. However, as is the case for the carbapenems, some penems ate extensively metabolized by human renal dehydropeptidase-1 enzyme (144). Although no penem has received approval for clinical use as of this writing, expectations ate high that future research and development will change that. 

Tanaka, M., Hohmura, T., Nishi, K., Sato, K., Hayakawa, I., Antimicrobial activity of DU-6681a, a parent compound of novel oral carbapenem DZ2640, Antimicrob. Agents Chemother. 1997, 42, 1260-1268. 

Hikida M, Itahashi K, Igarashi A, Shiba T, Kitamura M. (1999) In vitro antibacterial activity of LJC 11,036, an active metabolite of L-084, a new oral carbapenem antibiotic with potent antipneumococcal activity. Antimicrob Agents Chemother 43 2010-2016. 

Kobayashi R, Konomi M, Hasegawa K, Morozumi M, Sunakawa K, Ubukata K. (2005) In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus Pneumoniae. Antimicrob Agents Chemother 49 889-894. 

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