Carbamazepine genetic factors

Carbamazepine is a known potent enzyme inducer, which appears to increase the metabolism of risperidone by the cytochrome P450 isoenzyme CYP2D6 (although other isoenzymes may play a part). The extent of the interaction appears to be related to CYP2D6 genotype (see Genetic factors , (p.4)). Oxcarbazepine is not known to affect CYP2D6-mediated metabolism. 

Genetic factors associated with severe adverse skin reactions induced by antiepileptic drugs in different ethnic populations have been discussed [80 , 81" ]. Several studies have shown that Han Chinese patients carrying the HLA-B 1502 are at high risk of Stevens-Johnson syndrome or toxic epidermal necrolysis when exposed to carbamazepine. 

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