Carbamazepine and Other HLA-Drug Hypersensitivity Associations

The carbamazepine-HLA-B 15 02 interaction has also recently been used by S-1 Hung and collaborators in Taiwan as a model for the study of the pathologic role of HLA in delayed-type drug hypersensitivity. No intracellular metabolism or antigen processing was detected in the interaction between carbamazepine and HLA-B 15 02 in patients with the bullons skin 

The NSAID and phenylbutazone derivative, feprazone, was found to be associated with HLA-B22 in a Scandinavian study—93 % of patients with a fixed drug eruption caused by the drug were HLA-B22 positive but no patients with fixed drug eruptions to other drugs were positive to HLA-B22 and this allele was found in 4 % of healthy controls. However, a number of factors, including the absence of HLA-B22 in 7 % of the Scandinavian patients with feprazone-induced fixed drug eruption, need further scrutiny before feprazone-HLA-B22 can be taken as a diagnostic marker. At the least, more extensive population studies are needed. 

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