Carbamates vulnerabilities

In resistant green rice leafhopper, an acetylcholinesterase with reduced affinity for N-methyl carbamate insecticides had increased sensitivity to inhibition by longer N-alkyl groups however, the inverse relationship was observed against the susceptible enzyme (21). The optimal substitution appeared to be N-(n-propyl) and the use of this chemistry in a resistance breaking strategy was discussed. Unfortunately, N-(n-propyl)propoxur was inhibitory of neither susceptible nor resistant acetylcholinesterase of predatory mites, Amblyseius potentillae so that this type of vulnerability is not common to all resistant acetylcholinesterases (22)-... 

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