Carbamates N-alkylation

Much greater differences are observed when bulk tolerances are considered in the binding step prior to Irreversible inhibition. Though not the subject of this paper, differences in bulk tolerance at the esteratic site between OC s and OP s are simply Immense in molecular terms. The carbamate N-alkyl group is limited in size to methyl for commercial activity while phosphates, phosphoramidates, and phosphonates typically accommodate Isopropyl and phenyl groups. The variation is extensive, however, with some esteratic sites (OP resistant mites) (18), unable to accept an 0,0-dimethylphosphoryl group while others (electric eel AChE) are able to bind a dlphenyl-phosphinyl group (19). 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

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