Trehalosamine carba

Coupling of 237 with the protected 2-amino-2-deoxy-o -D-glucopyranosyl bromide (348) in dichloromethane in the presence of silver triflate afforded a diastereoisomeric mixture. The isomer related to the natural one was depro-tected with sodium in liquid ammonia, to give the carba-trehalosamine... [Pg.72]

Carba-trehalosamine was found to show 25% of the activity of 2-treha-losamine, which showed that, in biologically active oligosaccharides, re-... [Pg.88]

Such carba-disaccharides as validoxylamines A and B were synthesized as intermediary compounds in the total synthesis of validamycin antibiotics. Carba-disaccharides related to maltose, isomaltose, cellobiose, the trehaloses, and trehalosamine modifications have also been synthesized. [Pg.90]

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