Probenecid Captopril

ACE INHIBITORS PROBENECID t plasma concentrations of captopril and enalapril uncertain clinical significance Renal excretion of captopril and enalapril l by probenecid Monitor BP closely... [Pg.42]

Probenecid decreases the renal clearance of captopril, but this is probably not clinically important. Probenecid decreases the renal clearance of enalapril, and raises its serum levels. [Pg.32]

Steady-state levels of unchanged and total captopril, given by intravenous infusion, were slightly increased (14% and 36%, respectively) by the use of probenecid in 4 healthy subjects. Renal clearance of unchanged captopril decreased by 44%, but total clearance was reduced by only 19%. These moderate changes are unlikely to be clinically important. [Pg.33]

Singhvi SM, Duchin KL, Willard DA, McKitistty DN, Migdalof BH. Renal handling of captopril effect of probenecid. Clin Pharmacol TTjer (1982) 32, 182-9. [Pg.33]

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