Capillary zone electrophoresis hyphenated techniques

Dedicated applications of capillary zone electrophoresis (CZE) coupled to MS are discussed, particularly in the field of drug analysis. Development of other capillary-based electrodriven separation techniques such as non-aqueous capillary electrophoresis (NACE), micellar electrokinetic chromatography (MEKC), and capillary electrochromatography (CEC) hyphenated with MS are also treated. The successful coupling of these electromigration schemes with MS detection provides an efficient and sensitive analytical tool for the separation, quantitation, and identification of numerous pharmaceutical, biological, therapeutic, and environmental compounds. 

The combination of capillary zone electrophoresis or CIEF with inductively coupled plasma (ICP) MS promises a powerful tool for metal speciation. The on-line hyphenation of these techniques resulted in short separation times (10 min) and a subsequent detection step lasting 100 s. Standard mixtures and body fluids such as human milk and serum have been studied [65],... 

---