Cannabinoid receptor agonists 760 Subject

The papers listed in Table 3 and discussed in the preceding paragraph represent in vitro studies, and the question arises whether similar results are also obtained in vivo. This was examined in a series of studies on rats subjected to in vivo microdialysis the ligands under study were administered intraperitoneally or intravenously. Cannabinoids indeed decrease acetylcholine release in the dorsal hippocampus (Mishima et al. 2002). In the studies by Tzavara et al. (2001,2003a), in which cannabinoid agonists were not studied themselves, the CBi receptor inverse agonist SR 141716, which elicits effects opposite in direction to those of cannabi-... 

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