Cancer chemoprevention arachidonic acid

Arachidonic acid metabolites have received tremendous attention for their role in carcinogenesis. A link among the enzymes, metabolites, and receptors involved in the Cox and Lox pathways has been established to inflammation and a variety of cancers. Aberrant arachidonic acid metabolism has been shown to play a major role in the development and progression of several cancers. Both the Cox and Lox pathways have been linked to cell proliferation, inhibition of apoptosis, and promotion of angiogenesis. In addition, several clinical, in vitro, and in vivo studies have been conducted to demonstrate the chemopreventive activity of several Cox-2 and 5-Lox inhibitors on several models of cancer. - ... 

Levine L (2003a) Does the release of arachidonic acid from cells play a role in cancer chemoprevention FASEB J 17(8) 800-802... 

Marks, F., Muller-Decker, K., and Furstenberger, G., A causal relationship between unscheduled eicosanoid signaling and tumor development cancer chemoprevention by inhibitors of arachidonic acid metabolism, Toxicology, 153, 11, 2000. 

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