Cancer biology neoplastic transformation

In recent decades, the development of chemical, biochemical, and biological techniques has allowed the creation of analytical tools which can be used to facilitate the identification of the mechanisms involved in neoplastic transformation. Animal models remain, however, the most widely used approach of investigation. Cancer bioassays are usually conducted in rodents (rats and mice) and the experimental protocol takes 18-24 months and it is followed by extensive histopathological and statistical analysis. The procedure is time and... 

One class of redox analytes for which diamond ofiers a somewhat unique response, especially in the carbon electrode family, is the electrooxidation of aliphatic polyamines, such as cadaverine (H2N-(CH2)5-NH2). Polyamines are ubiquitous components of all cells and are known to play critical roles in the proliferation, difierentiation, maintenance, and neoplastic transformation of mammalian cells [159]. Polyamines are known to be involved in angiogenesis—a process essential for tumor growth and metastasis (biological markers for cancer) [160,161]. 

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