Camptothecin radiation sensitization

Rich TA, Kirichenko AV. Camptothecin radiation sensitization mechanisms, schedules, and timing. Oncology (Huntingt) 1998 12(8 Suppl 6) 114-120. 

The rationale for combining 9-AC with irradiation was based on in vitro work with human colon and pancreatic cancer cell lines showing dose dependency for cytotoxicity and radiation sensitization and other reports that it is a potent radiation sensitizer in vivo (21). Unfortunately, this agent is not very well tolerated in man and clinical studies have been abandoned (12). Another agent is 9-nitro-camptothecin that is converted into 9-AC in vivo, which has also been shown to be active in vitro and in vivo (44,45). 

LCLs derived from targeted populations have been utilized to evaluate genetic susceptibility to radiation sensitivity (9), sensitivity to mitomycin C in patients with Wilms tumor (10), and camptothecin-induced apoptosis (11). These cell lines have been useful for studying bleomycin-induced chromatid breaks and oxidant-induced apoptosis (12)... 

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