9-nitro-camptothecin

Other Agents 9-Amino-Camptothecin, 9-Nitro-Camptothecin... 

The rationale for combining 9-AC with irradiation was based on in vitro work with human colon and pancreatic cancer cell lines showing dose dependency for cytotoxicity and radiation sensitization and other reports that it is a potent radiation sensitizer in vivo (21). Unfortunately, this agent is not very well tolerated in man and clinical studies have been abandoned (12). Another agent is 9-nitro-camptothecin that is converted into 9-AC in vivo, which has also been shown to be active in vitro and in vivo (44,45). 

Pantazis P, Harris N, Mendoza J, Giovanella B. Conversion of 9-nitro-camptothecin to 9-amino-camptothecin by human blood cells in vitro. Eur J Haematol 1994 53(4) 246-248. 

Bernacki RJ, Pera P, Gambacorta P, Brun Y, Greco WR. In vitro antitumor activity of 9-nitro-camptothecin as a single agent and in combination with other antitumor drugs. Ann N YAcad Sci 2000 922 293-297. 

Verschraegen, C. F, Gilbert, B. E., Loyer, E., Huaringa, A., Walsh, G., Newman, R. A., et al. (2004), Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignancies, Clin. Cancer Res., 10, 2319-2326. 

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