Calteridol calcium

Benzyl chloride Butyl paraben Caldiamide sodium Calteridol calcium Cellulose (microcrystalline)... 

Calteridol calcium is used as a chelating excipient in a parenteral formulation and was chosen as an example for two reasons. It contains water associated with a metal cation and thus represents a Class 3 hydrate. In addition, water is also contained in channels, as with the second example. What is unique about the calteridol system is that a single crystal structure has been solved for the tetra-decahydrate (reactant) and the tetra-dihydrate (product) using the same crystal. This procedure permits an interesting look not only into the structural differences but also into the energetic differences of the water environment through thermal analysis. A similar study was performed on the dihydrate and trihydrate phases of di-sodium adenosine 5 -triphosphate [25]. 

Figures 21a and b, 22a and b, and 23a and b contain the DSC, TGA, and XRPD data for the two hydrate phases of calteridol calcium. The DSC thermogram exhibits a large broad endotherm beginning at ambient temperature and peaking at approximately 75°C, which is associated with a weight loss of 13.56% (based on dry weight) or eight moles of water (calculated 13.96%). Further heating shows a smaller...

Following the procedures described above, the other neutral macrocyclic extracellular contrast agent, gadoteridol (ProHance), (Fig. 5.3) can be produced in an anologous way [32]. As an additive, the calcium salt of the calcium chelate of the ligand (calteridol) is used in the pharmaceutical formulation, prepared by treatment of the ligand l,4,7-triscarboxymethyl-10-(2-hydroxypropyl)-l,4,7,10-tetraazacyclododecane with an aqueous suspension of CaC03 [34]. 

In this procedure the pentameglumine salt of the ligand DTPA was added to prevent any undesired release of the gadolinium ion from the chelate. Gadolinium-complex formulations normally contain a small amount of excess ligand either in its free or calcium-complexed form. As mentioned above, Pro-Hance (gadoteridol) contains calteridol, the calcium salt of the relatively weak calcium complex of the ligand for instance. 

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