Calixarene core systems

Inhibition of protein-protein interactions offers a potential target for medicinal chemists. Hamilton et al. have illustrated this approach through the synthesis of a range of calixarene derivatives that bind to and inhibit chy-motrypsin. The calixarene core in these molecules is appended with anionic peptide domains, which are spatially matched to positively charged domains on the chymotrypsin surface, resulting in strong electrostatic attraction. This approach has recently been extended to self-assembled systems that utilize a quadruplex DNA core. °... 

Liimane et al. have attempted to use the calixarene framework 21 as a core on which to develop novel saccharide selective systems [70]. Observed pp for 21 were 115 for D-fructose and 24 for D-glucose in 33.3 wt% methanol-water at pH 7.77 (phos-... 

The pleated loop conformation was also found in the solid state structures of a monopotassium salt of C[8] reported by Fronun [94a] and obtained by its treatment with K2CO3 in a two-phase H2O/THF system. The macrocycles are supramolecularly stacked one over the other to give a one-dimensional system with an inner coaxial channel (Fig. 7.27). A 10-molecule water cluster with a distorted cubane core is sandwiched between two cmisecutive calixarenes [94a]. 

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